One of the main arguments for New Horizons 2 is that it could fly by a really big second known KBO with a large moon (as well as flying by Uranus and its moons fairly near their equinox). This wasn't quite strong enough an argument for me to push it in print as I did NH 1 -- although, if the manned program hadn't been eating up NASA's budget like popcorn, I WOULD have pushed it. But it's a safe bet that virtually every probe launched to solar escape velocity from now on will take advantage of the opportunity to fly by at least one already-known KBO, given the extreme importance of observing a fair-sized sampling of them (which the seminal 2002 Decadal Survey report actually described as more important than flying by Pluto specifically).
In particular, there's a good chance that at least one or two of the future New Frontiers missions in the next decade or two will fly by one of the giant planets and drop off one or more atmospheric entry probes -- and it would be insane not to then use that craft to visit a KBO as well. (Plus a Centaur object or one of Jupiter's Trojan asteroids, should the opportunity for either present itself.)