New Horizons is going to be launching a Parallax Program this year - with planned simultaneous observations from Earth and New Horizons of Proxima Centauri and Wolf 359 on April 22nd and April 23rd.
At New Horizons distance the change in position for those two will be very noticeable - over an arcsecond - and the combined 3-d image should have some noticeable "pop" for those two stars versus other background ones.
As always this decade, the latest photo ever taken by New Horizons will be the Farthest Ever Taken.