In no particular order.
1. You find yourself saying stuff like 256 million pixels. Bah. That's not that much data...
2. You realize that any part of Mars can be interesting, if viewed at sufficient resolution.
3. You start to see in black and which away from the "Center strip" of your eyes.
4. You have decided to buy a 100+ Gbyte harddrive just to store your favorite HiRISE Images.
5. Your monitor only has 1600x1200 resolution, and you're considering getting a new one just to see more of the HiRISE Images.
6. You've ever heard of JPEG 2000.
7. You start throwing the word Hi at the begining of words (HiAlarm, HiPeople, HiWords, HiMate, etc)
8. You grow excited for each Wednesday, and prepare to download more HiPictures that day.
9. You've ever had a debate with someone about the complexities of imagine a spacecraft from another spacecraft in orbit around another planet.
10. You expect some day we'll know the truth about Beagle 2, MPL, and the final location of Sojourner, and possibly the Russian Mars landers.